🔗 Share this article Users Coming Off Anti-Obesity Medications Put On Weight at a Quadrupled Rate Compared to People Using Diet and Exercise Obesity treatment involves ongoing approaches. New research reveals that people who come off new weight-loss injections like Mounjaro or Wegovy can put back on shed pounds far faster than those who halt conventional lifestyle programs. Findings released in a leading medical journal shows that while obese people can lose substantial amounts of their body weight while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month upon discontinuation. "Individuals using these treatments need to be informed of the risk of fast rebound weight gain when the treatment is stopped," cautioned researcher Dr. Susan Jebb. This pace of regain means a reversion to pre-treatment mass in about 18 months. Comparing Treatments The study, which reviewed dozens of studies involving thousands of participants, contrasted the outcomes of GLP-1 agonists with older methods. Scientists point out that people who shed pounds through lifestyle changes alone generally have a slower weight regain—approximately 0.1 kg a month—post-intervention. The Reason for the Quick Regain Experts believe the way of the injections explains the amplified weight return. The injections copy a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness. "Sustained high doses of the hormone levels several times higher than the body's typical production may cause the body to produce less of its endogenous hormone, and could reduce sensitivity to its effects," explained Dr. Adam Collins, a nutrition specialist. "Discontinuation of this hormone supplement leads to appetite is uncontrolled, making excessive eating far more likely." A Lifelong Issue? Medical guidelines suggest the injections for people with weight-linked health risks, accompanied by recommended diet and exercise modifications. Many experts argue that, given the likelihood of weight regain, the treatment is often long-term. This view is supported by drug manufacturers, who state that the results "underscore the persistent character of obesity," comparing it to managing conditions like diabetes. User Accounts Individuals who have discontinued the jabs explain a powerful return of appetite. "It felt as if something flipping and you become ravenous," described one woman. This difficulty is exacerbated if patients have not developed sustainable lifestyle or habit changes during therapy. Widespread Use Recent estimates suggest that a significant number of people in the UK have used these injections in the past year, with desire continuing to grow. Adoption is greater among women compared to men. The middle-aged age group shows the greatest level of interest. Many obtain the medications through private prescriptions rather than public health services. Ultimately, experts stress that while GLP-1 drugs are powerful tools for shedding pounds, they are not a standalone cure and lasting health benefits hinges on integrated lifestyle management.
Obesity treatment involves ongoing approaches. New research reveals that people who come off new weight-loss injections like Mounjaro or Wegovy can put back on shed pounds far faster than those who halt conventional lifestyle programs. Findings released in a leading medical journal shows that while obese people can lose substantial amounts of their body weight while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month upon discontinuation. "Individuals using these treatments need to be informed of the risk of fast rebound weight gain when the treatment is stopped," cautioned researcher Dr. Susan Jebb. This pace of regain means a reversion to pre-treatment mass in about 18 months. Comparing Treatments The study, which reviewed dozens of studies involving thousands of participants, contrasted the outcomes of GLP-1 agonists with older methods. Scientists point out that people who shed pounds through lifestyle changes alone generally have a slower weight regain—approximately 0.1 kg a month—post-intervention. The Reason for the Quick Regain Experts believe the way of the injections explains the amplified weight return. The injections copy a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness. "Sustained high doses of the hormone levels several times higher than the body's typical production may cause the body to produce less of its endogenous hormone, and could reduce sensitivity to its effects," explained Dr. Adam Collins, a nutrition specialist. "Discontinuation of this hormone supplement leads to appetite is uncontrolled, making excessive eating far more likely." A Lifelong Issue? Medical guidelines suggest the injections for people with weight-linked health risks, accompanied by recommended diet and exercise modifications. Many experts argue that, given the likelihood of weight regain, the treatment is often long-term. This view is supported by drug manufacturers, who state that the results "underscore the persistent character of obesity," comparing it to managing conditions like diabetes. User Accounts Individuals who have discontinued the jabs explain a powerful return of appetite. "It felt as if something flipping and you become ravenous," described one woman. This difficulty is exacerbated if patients have not developed sustainable lifestyle or habit changes during therapy. Widespread Use Recent estimates suggest that a significant number of people in the UK have used these injections in the past year, with desire continuing to grow. Adoption is greater among women compared to men. The middle-aged age group shows the greatest level of interest. Many obtain the medications through private prescriptions rather than public health services. Ultimately, experts stress that while GLP-1 drugs are powerful tools for shedding pounds, they are not a standalone cure and lasting health benefits hinges on integrated lifestyle management.